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SCIENCE OF NITRIC OXIDE

Nitric Oxide is a simple molecule, made up of one part nitrogen and one part oxygen. Scientists and researchers around the globe have been astonished by the seemingly limitless list of the functions of Nitric Oxide in the body.

“In my 25 years of research, I have never seen a molecule that so pervasively influences normal and abnormal body functions,” said Dr. Solomon Snyder, the director of neuroscience at Johns Hopkins Medical School.

Despite the significance of this molecule, Nitric Oxide is relatively unknown outside the medical research community. Nitric Oxide is a highly reactive gas that is naturally produced in the human body.

Nitric Oxide is the most important signaling molecule in the body. It supports a wide range of physiological functions including healthy circulation, proper inflammatory response, normal learning and memory, correct digestion, and correct oxygen release in tissues from red blood cells.

It plays a significant role in many important chemical reactions. With today’s fast-paced lifestyle and factors like lack of exercise, poor diet, soil mineral depletion, cigarette smoke, and other air pollutants, supporting healthy levels of Nitric Oxide in humans is of critical importance.

Scientifically speaking, Nitric Oxide can be produced in the body through the process of converting Larginine (one of the 20 amino acids) into citrulline. However, more and more research suggests that Larginine has potentially negative side effects.

Additionally, many co-factors are required to convert Larginine into Nitric Oxide. Alternatively, Nitric Oxide can be produced more efficiently from substances known as nitrates and nitrites found in plants like Morinda Citrofolia (noni).

During 1999 and 2000, Dr. Thomas Burke and his researchers at Integrated Systems Physiology, an independent lab in Denver, Colorado, discovered that noni fruit juice was a raw material the body could use to synthesize Nitric Oxide.

Their findings helped to explain the enormous benefits some people had reported after consuming noni juice. Kyäni Nitro FX™ and Kyäni Nitro Xtreme™ were developed using a proprietary blend of noni concentrate to maximize the Nitric Oxide impact of Noni consumption.

These extraordinary products utilize groundbreaking research to unlock the secret of noni. “In my 25 years of research, I have never seen a molecule [like Nitric Oxide] that so pervasively influences normal and abnormal body functions.” -Dr. Solomon Snyder, Director of Neuroscience, John Hopkins Medical School

ADDITIONAL BENEFITS OF NITRIC OXIDE

Nitric Oxide positively affects nearly every system in the body, promoting better health and wellness. Well-documented for its role as a natural vasodilator, Nitric Oxide dilates the blood vessels, maintaining proper cardiovascular health. But that’s just the beginning. Look at how many more ways Nitric Oxide can benefit the human body…

Supports healthy fat burning within cells Assists the body’s natural wound-healing process Encourages normal lung health Promotes natural resistance to viruses and bacteria Maintains healthy digestive function Promotes natural restful sleep Helps maintain healthy blood sugar levels Fact:

If you cut off the oxygen to the heart, the heart will suffer irreversible damage or cell death in 5-7 minutes. If you terminate nitric oxide, it takes only 5 seconds. STUDIES ON NITRIC OXIDE McKnight, et al. “Chemical Synthesis of Nitric Oxide in the stomach from dietary nitrate in humans.”

Gut. 1997 Feb; 40 (2):211-4. GUO, et al. “Identification of a plant Nitric Oxide synthase gene involved in hormonal signaling.”

Science, 2003 Oct 3; 302(5642):100-3. Del Rio, L., Corpas, F. and Barrosos, J. “Nitric Oxide and Nitric Oxide synthase activity in plants.”

Phytochemistry 2004 Apr; 65(7):783-92 Schaffer, et al. “Nitric Oxide regulates wound healing.”

Surg Res. 1996; 63: 237-240 Taubert, et al. “Aspirin induces Nitric Oxide release from vascular endothelium: a novel mechanism of action.”

British Journal of Pharmacology 2004; 143: 159-165. Hancock, C. and Riegger-Krugh, C. “Modulation of pain in osteoarthritis: the role of nitric oxide.”

Clin J Pain. 2008 May;24(4):353-65. Jeschonneck, et al. “Abnormal microcirculation and temperature in skin above tender points in patients with fibromyalgia.”

Rheumatology (Oxford). 2000; 39:917-921. Akerstrom, et al.,“Nitric Oxide inhibits the replication cycle of severe acute respiratory syndrome coronavirus.”

Center for Microbiological Preparedness, Swedish Institute for Infectious Disease Control. J Virol. 2005 Feb;79(3):1966-9. ncbi.nlm.nih.gov Nitric oxide:

From menace to marvel of the decade nitromd.com Reproductive and Cardiovascular Disease Research Group squl.ac.uk Arthritis Research & Therapy arthritis research UC Irvine researchers reveal structure of molecule that regulates blood pressure ucihealth.com

The Building Blocks of Erection: Nitric Oxide . . . and More Nitric Oxide hopkinsmedicine.org

Spiraling high blood pressure linked to Nitric Oxide deficiency ucihealth.com NITRIC OXIDE

PREVENTS BLOOD VESSEL INFLAMMATION hopkinsmedicine.org NITRIC OXIDE LINKS BULK OF SPORADIC AND FAMILIAL PARKINSON’S DISEASE hopkinsmedicine.org

Study Points to Role of Nitric Oxide in New Treatments for Sickle Cell Anemia nih.gov Cortical feedback to the thalamus is selectively enhanced by nitric oxide.

ncbi.nlm.nih.gov Nitric Oxide Deficiency Raises Cardiovascular Disease Risk in African Americans news.research.ohiou.edu Study:

Nitric Oxide Key to Brain ‘Booting Up’ foxnews.com

Heart Disease Risk Factor #1: Nitric Oxide rd.com

Nitric Oxide Converted in the Stomach McKnight, G.M., et al., “Chemical synthesis of Nitric Oxide in the stomach from dietary nitrate in humans.” Gut. 1997; 40: 211-4.

Nitric Oxide and the Blood “Duke researchers discover the central role of Nitric Oxide in hemoglobin action.” Duke Medicine News and Communication. 3 Nov. 2004. dukehealth.org Gladwin, M., et al.

“Role of circulating nitrite and S-nitroso hemoglobin in the regulation of regional blood flow in humans.” Proc Natl Acad Sci U S A. 2000 Oct. 10; 97(21): 11482-7.

Blood flow and Alzheimer’s Mazza, M., et al., “Primary cerebral blood flow deficiency and Alzheimer’s disease: shadows and lights.” J Alzheimers Dis. 2011 Jan 1;23(3):375-89.

Bone Health Health News Report “Exercise and Vitamin D Help Prevent Falls in Seniors.” 2010 Dec 23. healthnewsreport.blogspot.com Nazrun, A.S., M. Norazlina, M. Norliza and S.I. Nirwana, 2011.

Tocotrienols as an anti-osteoporotic agent: The progress so far. Int. J. Osteoporosis Metab. Disorders, 1: 1-14.

“Nitric oxide: the novel therapy for osteoporosis.” Expert Opin Pharmacother. 2008 Dec;9(17):3025-44. Nitric Oxide and Recovery Diwan, A., et al.

“Nitric Oxide modulates fracture healing.” J Bone Miner Res. 2000 Feb;15(2):342-51.

THE ABILITY OF SAMPLES TO MODULATE ANGIOGENESIS Summary The extract of Kyäni’s proprietary noni blend was tested at two concentrations in the presence and the absence of Vascular Endothelial Growth Factor (VEGF) for its ability to inhibit angiogenesis using the aortic ring model.

The rings treated with VEGF alone exhibited growth of the microvessels over the 7 days of the investigation. At no one point of time was any microvessel growth observed when the aortic rings were cultured in the presence of two different concentrations of Kyäni’s proprietary noni blend extract. Furthermore the two concentrations of noni blend also completely prevented any vessel growth in rings treated with VEGF

RESEARCH ON BLUEBERRIE

Researchers have found that blueberries contain many health-promoting properties including high levels of antioxidants. A study conducted by the US Department of Agriculture determined that blueberries have the highest total antioxidant capacity per serving when compared to 24 varieties of fresh fruits, 23 vegetables, 16 herbs and spices, 10 different nuts, and 4 dried fruits.

Due to the harsh growing conditions of Alaska, Wild Alaskan Blueberries have even higher nutritional values than common blueberries. In fact, studies have shown that Wild Alaskan Blueberries have at least ten times higher antioxidant levels than the common blueberry.

“When it comes to brain protection, there is nothing quite like blueberries. Call the blueberry the brain berry.” -Dr. James Joseph, Ph.D., Lead scientist in the Laboratory of Neuroscience at the USDA Nutrition Research Center On Aging at Tufts University ADDITIONAL STUDIES ON BLUEBERRIES:

Agricultural Research Magazine. U.S. Department of Agriculture: Agricultural Research Service. Nutrition and Brain Function:

Food for the Aging Mind. Aug. 2007. ars.usda.gov Andres-Lacueva C, Shukitt-Hale B, Galli RL, et al. Anthocyanins I aged blueberry-fed rats are found centrally and may enhance memory.

Nutr Neurosci. 2005 Apr;8(2):111-20. Faria A, Oliveira J, Neves P, et al. Antioxidant properties of prepared blueberry (Vaccinium myrtillus) extracts. J Agric Food Chem. 2005 Aug 24;53(17):6896-902.

Journal of Agricultural and Food Chemistry, 2004 Jun 16;52(12):4026-37

Journal of Agricultural and Food Chemistry, 2005 May 4;53(9):3403-7

Journal of Agricultural and Food Chemistry, 52:4026-4037, 2004 Kay CD, Holub BJ. The effect of wild blueberry

(Vaccinium angustifolium) consumption on postprandial serum antioxidant status in human subjects. BR J Nutr. 2002 Oct;88(4):389-98. Lau, et al.,

“The beneficial effects of fruit polyphenols on brain aging.” Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University. Neurobiology of Aging. 26S (2005) S128– S132. ddr.nal.usda.gov Underwood A.

So berry good for you; rediscovering the health benefits of berries. Newsweek. June 17, 2002. Daniells, Stephen. Blueberry powder may slow breast tumor growth: Mouse data. Nutra ingredientsusa.com. Sept 20, 2011

SCIENCE TOCOTRIENOLS

Tocotrienols (bixa orellana) are part of the Vitamin E family. Tocotrienols were originally discovered by Pennock and Whittle in 1964. In the early 1980s, Tocotrienols were shown to help maintain healthy cholesterol.

Since then, Tocotrienols have been studied extensively in numerous clinical trials and are proven effective in supporting proper blood cholesterol levels in healthy individuals.

TOCOPHEROLS AND TOCOTRIENOLS: THE VITAMIN E FAMILY Tocopherol (T) 5. Alpha-T 6. Beta-T 7. Gamma-T 8. Delta-T Tocotrienols (T3) 1. Alpha-T3 2. Beta-T3 3. Gamma-T3 4.

Delta-T3 STUDIES ON TOCOTRIENOLS Tocotrienol – Wikipedia Graveline, Duane. Tocotrienols in Combat: Fighting the Statin Damage Crisis.

Whole Foods Magazine. Oct. 2011. Whole Foods Magazine TOCOTRIENOLS AND HEART HEALTH Pearce BC, Parker RA, Deason ME, Qureshi AA, Wright JJ (October 1992).

“Hypocholesterolemic activity of synthetic and natural tocotrienols”. J. Med. Chem. 35 (20): 3595–606. doi:10.1021/jm00098a002. PMID 1433170. ^ Tan DT, Khor HT, Low WH, Ali A, Gapor A (April 1991).

“Effect of a palm-oil-vitamin E concentrate on the serum and lipoprotein lipids in humans”. The American Journal of Clinical Nutrition 53 (4 Suppl): 1027S–1030S. PMID 2012011.

Pearce, B.C., et al., Hypocholesterolemic activity of synthetic and natural tocotrienols. Med Chem, 1992. 35(20): p. 3595-606. Kooyenga, D.K., et al., Antioxidants modulate the course of carotid atherosclerosis:

A four-year report., in Micronutrients and Health, K. Nesaretnam and L. Packer, Editors. 2001, AOCS Press: Illinois. p. 366-375. Tan, B. and A.M. Mueller, Tocotrienols in Cardiometabolic Diseases., Tocotrienols:

Vitamin E beyond Tocopherol, R. Watson and V. Preedy, Editors. 2008, AOCS/CRC Press. p. 257-273. Naito, Y., et al., Tocotrienols reduce 25-hydroxycholesterol-induced monocyte-endothelial cell interaction by inhibiting the surface expression of adhesion molecules. Atherosclerosis, 2005. 180(1): p. 19-25.

ASTAZANTHIN Fassett, R.G. and J.S. Coombes, Astaxanthin, oxidative stress, inflammation and cardiovascular disease. Future Cardiol, 2009. 5(4): p. 333-42.

Tocotrienols and Cancer Cells Shibata, A., et al., delta-Tocotrienol suppresses VEGF induced angiogenesis whereas alpha-tocopherol does not. J Agric Food Chem, 2009. 57(18): p. 8696-704. Miyazawa, T., et al., Antiangiogenic and anticancer potential of unsaturated vitamin E (tocotrienol). J Nutr Biochem, 2009. 20(2): p. 79-86.

TOCOTRIENOLS AND RADIATION Kulkarni, S., S. P. Ghosh, et al. “Gamma-tocotrienol protects hematopoietic stem and progenitor cells in mice after total-body irradiation.” Radiat Res 173(6): 738-47. Ghosh, S. P., S. Kulkarni, et al. (2009).

“Gamma-tocotrienol, a tocol antioxidant as a potent radioprotector.” Int J Radiat Biol 85(7): 598-606. Satyamitra, M. M., S. Kulkarni, et al. “Hematopoietic Recovery and Amelioration of Radiation-Induced Lethality by the Vitamin E Isoform delta-

Tocotrienol.” Radiat Res 175(6): 736-45. Li, X. H., D. Fu, et al. “Delta-tocotrienol protects mouse and human hematopoietic progenitors from gamma-irradiation through extracellular signal-regulated kinase/mammalian target of rapamycin signaling.” Haematologica 95(12): 1996-2004

 

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